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Deficiencies in vitamin B12 (particularly in patients also taking metformin), iron, and other nutrients have been linked to cognitive symptoms
doi: 10.3389/fcimb.2022.957439 82 MaY.HuC.YanW.JiangH.LiuG
Jeyakumar Y, Richardson L, Sarma S, Retnakaran R, Kramer CK
However, owing to the lack of consideration for brain capillary binding or sequestration, the reliability of these results regarding brain uptake pharmacokinetics has been questioned [21] as well as whether results could be translated into humans
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