Regarding fibrosis, while direct anti-fibrotic mechanisms are less established, preclinical studies indicate that GLP-1 RAs could suppress fibrogenic cell activation and reduce expression of pro-fibrotic genes encoding extracellular matrix proteins, potentially facilitating fibrosis regression in conjunction with improvements in steatosis and inflammation [29-32]
AUDIT scores were not different between controls with the GLP-1RA group (Range 16)
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Gil-Lozano M, Roman-Prez M, Outeirio-Iglesias V, Vigo E, Gonzlez-Matas LC, Brubaker PL, et al