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Semaglutide is well tolerated with no risk of hypoglycaemia in monotherapy but suffers from gastrointestinal adverse effects

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Compared to CAF HIGH, PXN HIGH reduced escape latency in old animals by approximately 12.1% ( P = 0.003)

Journal of Physiology-Paris , 112(1), 1-10

Stomach Pain on Reta vs Other GLP-1 Compounds Cross-trial comparisons have significant limitations, but directional data helps contextualize the stomach pain experience on retatrutide: Metric Retatrutide 12 mg Semaglutide 2.4 mg Tirzepatide 15 mg Overall GI events ~67% ~74% ~51% Nausea ~46% ~44% ~31% Diarrhea ~33% ~30% ~23% Vomiting ~22% ~24% ~12% Discontinuation due to GI AEs ~8% ~7% ~6% Key observation: Despite targeting three receptors instead of one or two, retatrutide's overall GI adverse event rate is comparable to semaglutide and modestly higher than tirzepatide