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When it outpaces neutralization by enzymes like superoxide dismutase and small-molecule antioxidants such as glutathione, harm builds up
The activity of these enzymes is enhanced by a variety of chemicals, including caffeine[40, 41] and anticonvulsant drugs[42], and it is well known that co-ingestion of these drugs with APAP can greatly enhance the toxicity of APAP
However, women should not take L-carnitine supplements during pregnancy or while breastfeeding without consulting with a healthcare provider due to the lack of safety data [8]
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