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For current clinical use, semaglutide has unmatched validation

That said, its always a good idea to consult your doctor first, especially if you plan to combine it with other supplements

J Mol Neurosci 48(3):684695

GLP-1 receptor agonists may reduce cancer risk among people with obesity or overweight, according to retrospective study results

Taking a proton pump inhibitor or other medications that reduce stomach acid for reflux or ulcers, as well as taking metformin for diabetes, can reduce absorption of B12 in food or supplements