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"The estimation of acetanilide and its metabolic products, aniline, N -acetyl p -aminophenol and p -aminophenol (free and total conjugated) in biological fluids and tissues"

Foundational mouse study (Baar et al., 2017, Cell) Designed FOXO4-DRI and showed selective senescent-cell clearance, with restored fitness, fur density, and kidney function in aged and chemotherapy-treated mice

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By immunohistochemical analysis, Ki67 and PCNA expressions were significantly higher in the experimental RRM2 -OE-TPC-1 group compared with the control group, while Ki67 and PCNA expressions were significantly lower in the experimental RRM2 -KD-TPC-1 group ( Figure 6H )