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According to Associate Professor Quang Bay, GLP-1 RA was initially an injectable drug used to treat type 2 diabetes, especially in people with pre-existing cardiovascular disease due to atherosclerosis
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Tirzepatide overcomes these limitations by simultaneously activating both GIPR and GLP-1R, thereby harnessing their complementary mechanisms of action [25]
Retatrutide represents a novel generation of research compounds in the anti-obesity and antidiabetic field, characterized by its unique mechanism of action involving the simultaneous activation of three metabolically relevant receptors: the GCG-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the GCG receptor (GCGR)
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