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In plain language, spironolactone can reduce the effect of androgens such as testosterone on your skin and hair follicles, which is why clinicians sometimes use it for female-pattern hair loss, hormonal acne, and excess body hair (hirsutism)

People with higher starting weights tend to lose more in absolute terms, while those closer to a healthy BMI may see smaller numbers but more significant body composition changes

Some compounded providers offer aggressive escalation

Minis E, Stanford FC, Mahalingaiah S

Because trials of ketogenic therapies neither last long enough, nor include enough participants (thousands or more), they cannot establish whether the effect on LDL cholesterol translates to an increased risk of heart disease in this context of carbohydrate restriction