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We also observed complete L-carnitine deficiency as a sign of complete impairment of L-carnitine synthesis in gbh-1(ko), gbh-1(G247Vfs*6) , and gbh-1(G283R) mutants (Fig

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The prognosis in these cases appears to be excellent, but the series of cases is small [111, 112]

Adults who tolerate 2.4 mg, still need additional weight reduction, and are accepting the higher-dose adverse-effect burden

The frequency of administration may decrease over time as well once the vitamin has been able to build up a bit in the body