Intramuscular (IM) vitamin injections bypass the gastrointestinal system entirely, achieving 70 to 80% greater bioavailability than oral supplementation
Conversely, IGF-1 acts to provide an inhibitory feedback signal on GH secretion in the hypothalamus by stimulating somatostatin production in the pituitary [8991]
These produce more pronounced effects but raise the chance of side effects such as insulin resistance, fluid retention and joint discomfort, and call for closer monitoring
The Liver King, n Brian Johnson, is a buff social media influencer who pressed his followers to adopt an ancestral lifestyle and stay away from chemicals, Wi-Fi signals, and modern bedding
Real-world dosing and outcomes 6-month persister loss about 12-13% (Hankosky DOM 2025), broad-cohort about -9.8% (Adamidis Cureus 2026), telehealth completers near -23% (Duncan Obesity Pillars 2026)