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10.3389/fphys.2022.814510 52 HoodE

This gap has led a growing number of people to look beyond the typical routetoward natural, science-informed alternatives

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This stimulates the synthesis and release of endogenous growth hormone. Growth hormone subsequently acts on the liver and other peripheral tissues, increasing: Insulin-like growth factor 1 Insulin-like growth factor binding protein 3 GH-dependent metabolic signaling Lipolytic and tissue-remodeling pathways In the Phase 3 studies, mean IGF-1 increased substantially during the initial 26-week treatment period

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