57 Phase 1b trial of GSBR-1290 (590 mg) in 24 healthy volunteers over 4 weeks demonstrated no study discontinuations due to AEs
Willard et al
Further, many available clinical-based studies had incomplete or an absence of details of the medication or patient demographics including medications, medical and/or surgical history, and other notable findings such as GI symptoms
MAPK participates in the intracellular signaling to: (1) induce the gene expression of redox sensitive transcription factors, such as activator protein-1 (AP-1) and nuclear factor B (NF-B) (Pinkus et al., 1996), (2) stimulate apoptosis (Clement and Pervaiz, 1999), and (3) modulate cell proliferation (Lundberg et al., 2000)
Njalsson R, Ristoff E, Carlsson K, Winkler A, Larsson A, Norgren S: Genotype, enzyme activity, glutathione level, and clinical phenotype in patients with glutathione synthetase deficiency