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Patients with genetic variations in GLP-1 receptors or related peptide pathways may experience enhanced response to semaglutide, while others show modest benefits
For patients prescribed to GLP-1 drugs for weight loss, up to 40% of the weight loss can be due to loss of muscle mass
Further randomized controlled trials and long-term observational studies are needed to validate its efficacy and safety profile
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Federal Lawsuits As of mid-2025, Novo Nordisk has filed more than 130 lawsuits across 40 states against telehealth companies and compounding pharmacies marketing and selling compounded semaglutide
