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It was first isolated from human plasma in 1973 by Loren Pickart, identified as the factor that caused aged human liver tissue to synthesize proteins like younger tissue
Before the discovery of ghrelin receptors, these were actually termed growth hormone secretagogue 1a receptors (GHS-R1a), and the molecules that might interact with them, like GHRP-6, are suggested to be growth hormone secretagogues (GHSs)
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