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Published preclinical work associates it with collagen and decorin regulation and with broad gene-expression shifts across ECM-related markers
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"Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes." Frontiers in Bioengineering and Biotechnology
Reviews have similarly concluded that paternal use of tyrosine kinase inhibitors, including imatinib, does not significantly impair fertility or offspring health
Key rule: Only increase if you have zero or manageable side effects at your current dose
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