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Drug resistance was defined as failure of adequate trials of two tolerated and appropriately chosen and used ASM schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom, according to the consensus recommendation of the International League Against Epilepsy (ILAE)
Allosteric regulation of ARs transcriptional activity The mechanistic insights reported above are consistent with allosteric regulation of transcription factor action, in which the type of DNA motif to which the factor binds and its protein and ligand interactions influence its conformational plasticity and the availability of tunable multimerization and protein interaction surfaces that control context-dependent and gene-specific transcriptional activity [78, 80]
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Front Cell Infect Microbiol (2013) 3:58
Relying on it too heavily could contribute to imbalanced dietary patterns or undereating, especially for individuals on GLP-1 medications who may already struggle to meet their needs due to significant appetite suppression, says McGowan
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