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Within the region replaced in chimera M8, 34 amino acids are different between MRP1 and MRP2
Studies document effects on 31.2% of human genes (approximately 4,000+ genes) with 50% expression change, suppressing RNA production in 70% of 54 genes overexpressed in metastatic colon cancer
Heat stress-related proteins may serve as markers for disease staging and guide clinical treatment decisions
Chakraborty et al., 2020
Cryo-sections were permeabilized, blocked with DAKO containing 0.1% saponin for 1 h, and then stained with Phalloidin antibody (Abcam, 1:1000)
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