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Smokers, pregnant women and consumers of stimulant drinks or drugs that could affect the effect of the study drug were excluded

Purchasers must be 18 years of age or older

Hydroxocobalamin in Neo-B12 Injection is the precursor for the enzyme co-enzyme B12 and this reacts with the enzyme Methylmalonyl Coenzyme A mutase, an isomerase required for the conversion of methylmalonate to succinate, an important step in production of lipoprotein in myelin sheath tissue, which could cause neurological problems

Eating smaller, more frequent meals rather than large ones reduces the nausea associated with gastric emptying changes

Gradual dose escalation exists to allow that pathway to accommodate