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Management of competing interests We used GIN principles to manage competing interests, including quarterly completion of the International Committee of Medical Journal Editors disclosure of interest forms by all members of the guideline panel and the McMaster Evidence Review and Synthesis Team.77 , 79 Obesity Canada adjudicated competing interests through its Clinical Practice Guideline Executive Committee

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Start at a low dose of 3 mg daily and increase the dosage after 4 weeks or 30 days, as prescribed by your healthcare provider

While half of patients took oral semaglutide daily, the other half only took a placebo

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