The GPx 18 genes are mapped to chromosomes 3, 14, 5, 19, 6, 6, 1 and 5 respectively.44 Among the glutathione peroxidases, GPx1 is the most abundant selenoperoxidase and is present virtually in all cells.45 GPx2 is found much more in the gastrointestinal tract primarily in the intestine.46, 47 The kidney relative to other tissues is the primary location for GPx3, though
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The mitochondria are the cells' energy generators
The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes
Infected cells can then be grown as immortalized lymphoblastoid cell lines (LCL), which model PTLD and CNS lymphomas, which express the EBV latency III program