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Insulin resistance means the body has trouble using insulin efficiently so more is produced to get the same effect
They appear to have less prominent effects on post-prandial glucose excursions, perhaps because the effects on gastric motility are decreased due to tachyphylaxis (29, 31)
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[170] [171] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [172] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk
Tomita T, Kuzuyama T, Nishiyama M
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