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Influence on the Nitric Oxide (NO) System BPC-157 also appears to affect the nitric oxide system, which helps regulate blood flow and immune responsesboth critical to tissue repair [8]
Sethi, S
Gnoni A, Longo S, Gnoni GV, Giudetti AM
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In experimental models, suppression of spermatogenesis in the testes and degeneration of primordial follicles and granulosa cells in the ovaries are considered hallmark features of platinum-induced gonadotoxicity.8 Chemotherapeutic agents have been shown to deplete intracellular Glutathione (GSH), one of the major endogenous antioxidants, while simultaneously increasing Myeloperoxidase (MPO) activity, an indicator of inflammatory response, and elevating Malondialdehyde (MDA), a marker of lipid peroxidation.9 Co-administration of antioxidants during chemotherapy has therefore been proposed as a strategy to mitigate oxidative stress-induced tissue injury and improve therapeutic tolerance
