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When monoglutamate folates are taken up into cells, particularly in the liver and kidney where they can be stored (but also in other cells), they are polyglutamated through the action of the enzyme folylpolyglutamate synthase

doi: 10.1016/j.tplants.2018.10.010 102 JouMJPengTIHsuLFJouSBReiterRJYangCMet al

Hypercholesterolemia increases mitochondrial oxidative stress and enhances the MPT response in the porcine myocardium: beneficial effects of chronic exercise

Chem Eur J 10:46644672 Cho CJ et al (2025) Diacylation of peptides enables the construction of functional vesicles for drug-carrying liposomes

By doing so, it helps reduce the risk of cancer