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Same biological axis, opposite mechanism positions AOD-9604 is downstream with isolated effects, tesamorelin is upstream with full axis activation
Therefore, it would be crucial to understand and outline the specific contribution of each cell type MN, glia, or others to ALS, in order to strategically target them with the NRF2 activators, thereby restoring neuronal homeostasis and survival, and functional MN-glia interactions (Fig
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