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Trends Food Sci Technol (2025) 156:205847

In scientific reports and clinical trials, a titration model was used to assess tolerance, safety and metabolic response as the concentration of the active substance was increased

doi: 10.3389/fendo.2021.678055 18 de GraafCDonnellyDWoottenDLauJSextonPMMillerLJet al

In triple-negative breast cancer (TNBC) xenograft mouse model, intraperitoneal injection of Retatrutide (5mg/kg) twice weekly for 5 weeks downregulated hexosamine biosynthetic pathway (HBP) activity and YAP protein levels, decreased the tumor volume, and enhanced the efficacy of chemotherapy [5]