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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy
Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain Palmitoylethanolamide (shortened to PEA) has anti-inflammatory and anti-hyperalgesic effects, due to the down-regulation of activation of mast cells Therapeutic potential of cannabinoids in trigeminal neuralgia there is growing evidence that cannabinoids may be effective in alleviating neuropathic pain and hyperalgesia [extreme pain sensitivity] via inhibiting neuronal transmission in pain pathways . All of the above can also improve mood and insomnia and reduce anxiety too
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