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While that's substantially higher than the 600mg starting dose we generally favor for people new to NAC, it reflects the GlyNAC protocols studied in healthy-aging research.34 57 58 Some readers may prefer to start with a smaller serving for tolerability, but the clinical research on GlyNAC has generally evaluated gram-level doses of both ingredients, so it's unclear whether substantially lower amounts would provide the same benefits
10.1126/scitranslmed.3007154 Sci Transl Med
Concerns could include underdosing, lack of clinical data on microdosing, and patients making decisions without guidance, Tebra researchers concluded
Beyond standard metabolic monitoring (weight, blood pressure, glucose, lipids), providers should regularly assess binge eating frequency, eating disorder cognitions, mood symptoms, and quality of life
10.1097/00004647-200001000-00015 45 SchapiraA
