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This was supported by recent studies showing that after exposure to an APAP overdose, hepatocytes, which express Cyp2E1 in mitochondria and in the ER, show protein adducts in both organelles but die through a mitochondria dysfunction-dependent necrosis [28]

Similarly, RvD2 levels were markedly reduced in MCAO animals, whereas intraperitoneal administration of exogenous RvD2 effectively reversed ischemic injury, as evidenced by reduced infarct size, attenuated brain edema, dampened inflammatory responses, and preserved neuronal function [174]

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Dosing tiers: Morning dosing is preferred because of its stimulatory effect on cellular metabolism