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Methylation, inflammation, and skin appearance B12 drives the methylation cycle, which among other functions helps regulate homocysteine an amino acid linked to inflammation and vascular stress when it accumulates

Those things can both be true.

As far as I know (I'm not medically trained or a scientist) overdosing B12 is unlikely as excess passes out in urine

Rotating injection sites prevents the development of localized tissue irritation or lipodystrophy (changes in subcutaneous fat)

Understanding what Myth: Youll Feel an Instant Energy Rush One of the biggest myths is that a B12 shot works like a cup of coffee, delivering an immediate jolt of energy