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This provides it a wide-ranging influence on weight and metabolism
( 5.10 ) 5.1Risk of Thyroid C-Cell Tumors In both sexes of rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology ( 13.1 )]
(2005) Mammalian selenoprotein thioredoxin-glutathione reductase
