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November 13, 2003
Do not eat grapefruit or drink grapefruit juice while you are using this medicine
An oral dose of 1 to 5 mg will raise serum melatonin levels to 10 to 100 times the normal levels within an hour.[ref] Taking melatonin during the day increases daytime sleepiness and drops body temperature (something that normally happens around the time you go to bed at night).[ref] Melatonin is easily absorbed orally, subcutaneously, intranasally, transdermally, and sublingually
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NICE guidelines should be influential and widely respected as a reference point across the UK because the process they have gone through before publication is extensive in terms of research and interested party feedback
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