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The pivotal PIONEER clinical trial programme, which included over 9,500 participants with type 2 diabetes, demonstrated consistent and clinically meaningful reductions in glycated haemoglobin (HbA1c)
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If anything feels unusual, it should be discussed with a healthcare provider
This is different from GLP-1s mechanism, which primarily reduces the drive to eat and the reward value of food through hypothalamic and mesolimbic circuits
Monitoring during tirzepatide therapy should include regular assessment of gastrointestinal tolerability, as severe nausea and vomiting can lead to dehydration and electrolyte disturbances that may indirectly affect cardiovascular stability
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