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Activating glucagon pathways may have metabolic advantages, but it also requires attention to glucose, heart rate, and overall tolerability
Given the unique risk of SAEs due to the potential for increased incidence of COVID-19 over the study period, we will also perform a sensitivity analysis where COVID-19 related SAEs will be excluded from the analysis
Liquid calories: minimize alcohol, sugary coffee drinks, and juicesthese often bypass satiety (Forbes explainer)
The use of DSIP typically requires a prescription, as it is a controlled substance
The SELECT cardiovascular outcomes trial established that semaglutide reduces major adverse cardiovascular events by 20%, providing a strong clinical rationale for treatment that extends beyond weight management alone
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