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Islets were obtained from normoglycemic donors, according to the local ethics rules (including next-of-kin consent) and isolation techniques, and cultured in RPMI supplemented with 5.5 mM d-glucose, 10% FCS, 100 U penicillin, 100 g streptomycin, and 0.25 g l 1 fungizone (37 C, 5% CO 2 ) 28
For individuals who are unable to achieve glycemic control with a lower dose, it may be necessary to switch to a higher dose
Together, these changes reflect a coordinated antioxidant response aimed at maintaining redox balance under elevated mitochondrial activity
We considered a P 10 weeks (Table 3)
The National Institute of Diabetes and Digestive and Kidney Diseases provides clinical context on how GLP-1 medications affect appetite regulation and energy balance
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