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83 Although animal research suggests hops do not strongly trigger proliferation in endometrial and breast tissues, there have been reports of endometrial thickening and bleeding in postmenopausal women using hops, and its long-term safety in women with a history or high risk of breast cancer is uncertain

The difference between once-daily and twice-daily dosing is noticeably but not dramatically so for most applications

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In some cases, healthcare providers may recommend an initial series of injections to quickly raise B12 levels, followed by maintenance injections at regular intervals