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Monitoring your health while using a GLP-1 receptor agonist is important, and certain symptoms or situations, such as the ones below, should prompt a consultation with a doctor: New or worsening gastrointestinal symptoms, such as persistent nausea, vomiting, diarrhoea, or signs of dehydration 7 , 27
Initial presentation scenarios warranting GP consultation include: Abnormal liver function tests (elevated ALT, AST, or GGT) detected during blood work or health screening Incidental finding of hepatic steatosis on ultrasound, CT, or MRI performed for other indications Persistent unexplained fatigue, particularly when accompanied by metabolic risk factors Right upper quadrant discomfort or sensation of abdominal fullness Presence of multiple metabolic syndrome components (central obesity, hypertension, dyslipidaemia, impaired glucose regulation) Urgent medical attention is required if symptoms suggest advanced liver disease or acute complications
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MHRA urges women taking weight loss drugs to use effective contraception
