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These include pancreatitis, gallbladder issues, and potential thyroid concerns (semaglutide carries a boxed warning about medullary thyroid carcinoma in animal studies)

Nutrient deficiencies: Appetite suppression can significantly reduce intake of essential vitamins and minerals

In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)

Its essential for enzymes like glutathione peroxidase , which helps neutralize and eliminate toxins

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