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10.1074/jbc.RA118.003278 47 LiH.HuangE.ZhangY.HuangS

Yes, they work through different mechanisms and may be complementary

Incidentally, the healthy reference range is 191-663 pg/ml and correlates closely with oral cobalamin intake, which is why the vitamin B12 blood level alone is not an adequate parameter to diagnose a deficiency (Herrmann and Obeid, 2014)