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Manual model building and structure refinement were carried out with PHENIX (version 1.20.1-4487) 29 , Coot (version 0.9.6) 30 and phenix-refine, respectively
The k red app values for the D90 and K26 mutants at 5 mM GSH were 78 and 5.6% of the k red app value for PfGrx C32S/C88S as a control
[6] References F
Bedaquiline does not induce or inhibit major CYP isoenzymes, namely, CYP1A2, CYP2C9, CYP2C19, or CYP2D6 at clinically relevant concentrations, minimizing the risk of CYP450-related interactions (Mesens et al., 2010)
