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Gastrointestinal side effects are the most frequently reported adverse reactions to GLP-1 receptor agonists, affecting a significant proportion of patients, particularly during initial treatment or dose escalation
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4 In contrast, Eli Lillys upcoming oral GLP1 candidate, orforglipron, is a smallmolecule drug rather than a peptide, which could lessen the need for dosing requirements and offer greater convenience to users
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