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ATP signaling is crucial for communication from taste buds to gustatory nerves

AstraZeneca said the Phase 1 data so far show a differentiating clinical profile with good tolerability and encouraging glucose and body weight reduction across the dose levels tested compared to placebo. The company had its own GLP-1 agonist in Phase 1 testing for diabetes, but discontinued it earlier this year as part of a strategic portfolio prioritization. It has another in testing for non-alcoholic steatohepatitis.

Transforming growth factor-beta family ligands can function as antagonists by competing for type II receptor binding

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