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Shengmai San Formula (SMS) modulates gut microbiota to elevate conjugated bile acids such as TCA, which stimulates Slit3 release from M2 macrophages in adipose tissue, activates the sympathetic nerve-norepinephrine axis, and promotes white adipose browning along with energy expenditure (266)

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One of the five peptides was removed from Category 2 in September 2024 and is currently undergoing PCAC review