Endocrinology (1987) 121:21128
highlighted the multifunctional properties of 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione, which exerts anticancer, anti-inflammatory, and neuroprotective effects through the modulation of critical signaling pathways such as the MAPK, JAK/STAT, NF-B, Nrf2, PI3K/Akt/mTOR, AMPK, and Wnt/-catenin pathways (Zhou et al
Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas
Early trials have confirmed pharmacodynamic markers such as interferon induction, T cell activation and local remodeling of cytokine profiles, but durable survival benefits remain to be established [76, 81, 83]
But after a few months, they recheck and then they see where its at