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Although the optimal dose of LC supplementation for myocardial infarction is 3 g/day in terms of all-cause mortality [90], even lower LC intake elevates fasting plasma TMAO [16,17,18, 58, 59], which is ten-fold higher than control after 3 months of supplementation [16, 17]
Oral semaglutide requires fasting administration (no food or drink except water for 30 minutes before and after the dose) and has higher gastrointestinal side-effect rates than injections because the drug saturates the gastric mucosa
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Patients on these medications should consult their healthcare provider before starting semaglutide therapy to determine whether temporary medication adjustment is safe or whether special injection precautions are needed
