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Semaglutide has revolutionized how we look at weight loss and the possibilities for medically treating it
The weight loss impact of semaglutide acted as a mediator for the decrease in SBP
In a meta-analysis 6 of eight trials with 60080 patients (ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O) , treatment with a GLP-1 receptor agonist led to a 14% relative risk reduction in three-point MACE (HR 086 [95% CI 080093]
Unfortunately, a doctors prescription from the USA/UK is not recognised in Singapore, and these patients will need to visit a Singapore licensed medical clinic to continue their treatment
The gastrocolic reflex is strongest after meals, so attempting to open the bowels after breakfast may be beneficial
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