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In addition, lower SIRT1 levels trigger the activation of apoptosis-related genes such as P66SHC and P53, which increases the susceptibility of hepatocytes to oxidative stress and programmed cell death
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It is hypothesized that this increase may correspond to a rise in fat pad weight relative to overall body mass, as suggested by DEXA scans, which appear to show a rise in body fat percentage
Measurement of intracellular and cell supernatant H 2 O 2 levels For intracellular and cell supernatant H 2 O 2 levels, 143B cells were plated in 6-well plates
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