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While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]
The most common side effects are mild: slight water retention, flushing, or injection site reactions
High levels of dietary fat impair glucose homeostasis in rainbow trout
p=0.01)
Should be administered under the direction of a licensed medical provider
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