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An intra-colonic injection of 180 mmol l 1 propionate (a total dose of ~0.45 mmol) vs saline control (matched for sodium content and pH) in anaesthetised rats resulted in a significant rise in circulating plasma PYY and GLP-1 levels (two-way ANOVA, effect of treatment P =0.024 and P =0.023, respectively)
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However, maximum effects require 45 weeks to reach steady-state drug levels, and significant outcomes develop gradually over months
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