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Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes

This interaction is mechanistically consistent with the observation that the protective effect of high broccoli intake against colorectal adenomas was exclusively evident in individuals with the GSTM1-null genotype, likely due to prolonged tissue exposure to bioactive ITCs (60)

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As an intracellular ion, Ca 2+ serves the role of a second messenger

3.2.1 Limitations of current AD treatments and the need for new approaches Despite continuous advancements in AD drug development, currently available treatments do not effectively halt or reverse disease progression