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This dual action is believed to offer a synergistic effect, resulting in greater improvements in blood sugar control and more significant weight loss than GLP-1-only medications

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They should be considered superior in most patients, including those with HF and CKD.3 However, ischaemia prevention is superior for GLP-1 RAs, thus making them preferable in patients with predominant ASCVD risk.3 Differences in routes of administration and adverse effect profiles may also play a role in prescription decisions

Leaf preparations are generally considered the safest form